Kubuntu 7.10 now includes WINE in the 64 bit version, a very welcome addition. WINE is a project to implement the Windows API in Linux, meaning that many Windows programs can run at native speeds on Linux. This is not an emulator, so memory and resource usage tends to be lighter.
Anxious to give this a go, I had a look at installing the OU FirstClass Client, a kind of groupware program for windows that handles conferencing and email messaging. This turned out to be very easy, in fact all I had to do was right click on the installer and select "Open With WINE" or words to that effect, and follow the wizard.
It seems to work pretty well, they may be problems but I have not found them yet. If you try this and find issues, feel free to post a comment of your experiences.
*** UPDATE ***
There is a native Linux version of FirstClass, check out Jo Badge's write up of how to get it working here:
She describes the process in relation to an Asus EEE PC - but the process should be very similar for other 32 bit Debian-based distributions (e.g. Ubuntu 32bit).